Process for making 3-substituted 2-amino-5-halobenzamides

Process for making 3-substituted 2-amino-5-halobenzamides

Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R 1 -NH 2 in the presence of a carboxylic acid, and the compound of Formula 2 may be prepared by contacting a compound of Formula 4 with phosphorus tribromide. wherein R 1 is H, C 1 -C 4 alkyl, cyclo...

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Bibliographische Detailangaben
Hauptverfasser: TAYLOR, ERIC, DEGUYON, DAVIS, RICHARD, FRANK, SHAPIRO, RAFAEL
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R 1 -NH 2 in the presence of a carboxylic acid, and the compound of Formula 2 may be prepared by contacting a compound of Formula 4 with phosphorus tribromide. wherein R 1 is H, C 1 -C 4 alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; R 2 is CH 3 or Cl; R 3 is C 1 -C 6 alkyl or C 3 -C 6 alkenyl, each optionally substituted with up to 3 halogen and up to 1 phenyl; and X is Cl or Br.