Methods of purifying anti A Beta antibodies

The present application provides methods of purifying A² binding proteins having a Fc region, for example, anti-A² antibodies or antibody fusions, by adsorbing the A² binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed A² binding protein. The present application also features methods of eluting the purified A² binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.