5,7-DIHYDRO-6H-PYRIMIDO[5,4-D][1]BENZAZEPIN-6-THIONES AS PLK INHIBITORS

5,7-DIHYDRO-6H-PYRIMIDO[5,4-D][1]BENZAZEPIN-6-THIONES AS PLK INHIBITORS

This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

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Bibliographische Detailangaben
Hauptverfasser: LI, GANG, BHARATHAN, INDU, T, VOS, TRICIA, J, GUO, JIANPING, REYNOLDS, DOMINIC, SOUCY, FRANCOIS, ELDER, AMY, M, DUFFEY, MATTHEW, O
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
ELECTROTHERAPY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
RADIATION THERAPY
ULTRASOUND THERAPY
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Beschreibung
Zusammenfassung:This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.