HETEROCYCLIC COMPOUNDS AND METHODS OF USE

In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compou...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, BRIAN, JOHN, TAO, ZHI-FU, NIKOLAKOPOULOS, GEORGE, BAELL, JONATHAN, BAYLDON, SOUERS, ANDREW, J, COLMAN, PETER, NDUBAKU, CHUDI, PETROS, ANDREW, M, WANG, XILU, DUDLEY, DANETTE, A, CZABOTAR, PETER, ELMORE, STEVEN, W, HASVOLD, LISA, A, LESSENE, GUILLAUME, LAURENT, BUI, CHINH, THIEN, WANG, LE, SLEEBS, BRAD, EDMUND, WATSON, KEITH, GEOFFREY, DESHAYES, KURT, FAIRBROTHER, WAYNE, J, FLYGARE, JOHN, A
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.