P38 MAP KINASE INHIBITORS

P38 MAP KINASE INHIBITORS

The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ONIONS, STUART, THOMAS, KING-UNDERWOOD, JOHN, ITO, KAZUHIRO, MURRAY, PETER, JOHN, WILLIAMS, JONATHAN GARETH, JOLY, KEVIN, STRONG, PETER, RAPEPORT, WILLIAM, GARTH, CHARRON, CATHERINE, ELISABETH
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.