Means and methods for identifying compounds altering nuclear localization of proteins

This invention relates to a eukaryotic cell comprising: (a) a first nucleic acid comprising a reporter gene under the control of a response element; (b) a second nucleic acid comprising a gene encoding a transcription factor, said transcription factor being capable of binding to said response elemen...

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Bibliographische Detailangaben
Hauptverfasser:	HILLEN, WOLFGANG, STOECKLE, CHRISTOPH, KLOTZSCHE, MARCUS, GOEKE, DAGMAR
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to a eukaryotic cell comprising: (a) a first nucleic acid comprising a reporter gene under the control of a response element; (b) a second nucleic acid comprising a gene encoding a transcription factor, said transcription factor being capable of binding to said response element, thereby controlling expression of said reporter gene; and (c) a third nucleic acid encoding a fusion protein, said fusion protein comprising: (i) a polypeptide of interest; and (ii) a peptide being capable of binding to said transcription factor, thereby controlling the activity of said transcription factor.