PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS

PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS

Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients sufferi...

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Bibliographische Detailangaben
Hauptverfasser: BLOMGREN, Peter, A, ORTWINE, Daniel, ZHAO, Zhongdong, YOUNG, Wendy, B, LEE, Seung, H, BARBOSA, Antonio, J., Jr, RENNELLS, William, M, CURRIE, Kevin, S, XU, Jianjun, ZHICHKIN, Pavel, E, SCHMITT, Aaron, C, KROPF, Jeffrey, E, MITCHELL, Scott, A
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.