MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY

MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY

Provided herein is a method for preparing a compound of formula (II):wherein the method comprising contacting a compound of formula (VI):with R1-Y in a solvent, in the presence of a palladium catalyst, wherein said contacting occurs in the presence of a base, wherein R1, R2, R3and Y are as defined h...

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Hauptverfasser: PAPA, Patrick, HARRIS, Roy, L, MADAKAMUTIL Loui, PACKARD, Garrick, LEE, Branden, TEHRANI, Lida, ZHAO, Jingjing, MORTENSEN, Deborah, SANKAR, Sabita, SAPIENZA, John, SHEVLIN, Graziella, PARNES, Jason, XU, Weiming, FULTZ Kimberly, ELSNER, Jan, PERRIN-NINKOVIC, Sophie, RIGGS, Jennifer, NARLA, Rama K
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein is a method for preparing a compound of formula (II):wherein the method comprising contacting a compound of formula (VI):with R1-Y in a solvent, in the presence of a palladium catalyst, wherein said contacting occurs in the presence of a base, wherein R1, R2, R3and Y are as defined herein.