PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIODONTAL DISEASES

A pharmaceutical composition for the treatment of periodontitis. A pharmaceutical composition according to the present invention is in the form of a gel with a selected viscosity. Its active ingredient is a base comprising a cysteine protease inhibitor from egg protein, urine, human or animal amniot...

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Hauptverfasser: MALOLEPSZA-JARMOLOWSKA, KATARZYNA, WNUKIEWICZ, BEATA, NIENARTOWICZ, JAN, BRYJAK, MAREK, SIEWINSKI, MACIEJ, WNUKIEWICZ, JAN, SEBZDA, TADEUSZ, TRZISZKA, TADEUSZ
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A pharmaceutical composition for the treatment of periodontitis. A pharmaceutical composition according to the present invention is in the form of a gel with a selected viscosity. Its active ingredient is a base comprising a cysteine protease inhibitor from egg protein, urine, human or animal amniotic fluid, human or animal placentae as well as plants, with an activity of 1 - 50 inhibition units, suspended in 50 g of a polyhydroxyl alcohol and 50 g of a 0.05 molar phosphate buffer solution at a p H of 6.0 to 7.5, from 20 to 50 % by mass, whereas its carrier comprises gelling substances, from 7 to 20 % by mass, as well as water to 100% by mass. The gelling substances may be methylcellulose, hydroxypropylmethyl-cellulose, carboxymethylcellulose sodium salt, gelatin, apple-citrus pectin or a dextran. Preferentially, additives in the form of polyhydroxyl alcohols and Nipagin are used.