ALZHEIMER'S DISEASE BIOMARKERS
The invention provides a biomarker for qualifying Alzheimer's disease status, the biomarker being detectable in a biological sample containing blood cellular elements and being derived from amyloid precursor protein or amyloid peptide. Particularly the biomarker includes an A 1-42 or A 1-43 spe...
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| Format: | Patent |
| Sprache: | eng ; fre ; ger |
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| Zusammenfassung: | The invention provides a biomarker for qualifying Alzheimer's disease status, the biomarker being detectable in a biological sample containing blood cellular elements and being derived from amyloid precursor protein or amyloid peptide. Particularly the biomarker includes an A 1-42 or A 1-43 species (monomer) and, or an A 1-42 dimer. An alternative or additional biomarker includes an APP cathepsin D cleavage product or includes a biomarker identifiable by a peak of molecular weight of about 9962 or 9980 Daltons when identified by SELDI-TOF MS utilising antibody WO2. |
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