[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid (acyloxy)alkyl or ((alkoxycarbonyl)oxy)alkyl ester as SPLA2 inhibitor

[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid (acyloxy)alkyl or ((alkoxycarbonyl)oxy)alkyl ester as SPLA2 inhibitor

The compounds [[3-(2-amino-1,2-diooethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid (acyloxy) alkyl or ((alkoxycarbonyl)oxy)alkyl ester are disclosed together with the use of the indole compound for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as se...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DILLARD, ROBERT DELANE, BACH, NICHOLAS JAMES, DRAHEIM, SUSAN ELIZABETH
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The compounds [[3-(2-amino-1,2-diooethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid (acyloxy) alkyl or ((alkoxycarbonyl)oxy)alkyl ester are disclosed together with the use of the indole compound for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.