Method for determining medication efficacy

The present invention relates to a method for determining medication efficacy, comprising: a) providing; i) a patient having a physiologic brain imbalance, wherein said imbalance is identified using a first electroencephalography recording, and ii) a medication; and, b) converting said first electroencephalography recording to at least one first multivariate outcome measurement wherein said first outcome measurement comprises a plurality of first univariate Z scores, wherein said first multivariate outcome measurement is derived from a frequency band selected from the group consisting of delta, theta, alpha, and beta; c) administering said medication to said patient; d) obtaining a second electroencephalography recording from said patient and converting said second electroencephalography recording to at least one second multivariable outcome measurement wherein said second outcome measurement comprises a plurality of second univariate Z scores, wherein said second multivariate outcome measurement is derived from a frequency band selected from the group consisting of delta, theta, alpha, and beta; and e) comparing said first multivariate outcome measurement with said second multivariate outcome measurement wherein a differential change between said first and second measurement determines said medication efficacy.