Modular Valve System and its use in a method for producing chemical and pharmaceutical products with integrated multi-column chromatography

In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the produ...

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Hauptverfasser:	STRUBE, JOCHEN, BOECKER, SEBASTIAN, GREIFENBERG, JOERN, NOETH, GERHARD, KANSY, HEINZ, JAEHN, PETER, JUSTEN, BERTHOLD, KLATT, KARSTEN-ULRICH
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BLASTING BRAKES CLUTCHES COUPLINGS FOR TRANSMITTING ROTATION DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS ORMACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS,CLIPS, WEDGES, JOINTS OR JOINTING ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS HEATING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIGHTING MEASURING MECHANICAL ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SEPARATION TESTING THERMAL INSULATION IN GENERAL TRANSPORTING WEAPONS
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Beschreibung
Zusammenfassung:	In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In the process the prior art 5-pump arrangement is replaced by a 4-pump arrangement. The process employs a single eluent constant flow feed pump and a single eluent compensation vessel and no circulation pump. The assembly employs no more than four pumps in the chromatography circuit. The prior art discharge pump, extract or refined discharge is replaced by a regulator valve. The automatic discharge of impure eluent in the circuit is facilitated by on-line detection and a regulator valve. Measurements made of the recyclate flow and the associated redundancy is increased by data comparison, increasing precision of the volumetric flow control. Independent claims are included for: (1) a modular valve system with a master plate, a valve housing, and a control unit housing, where the control system is located within an interior pneumatic chamber; and (2) a commensurate production process. Die Erfindung betrifft ein chromatographisches Verfahren zur Stofftrennung im Rahmen der Herstellung von Chemikalien wie z.B. chiralen Pharmazeutika, Isomeren oder Biomolekülen im Kleinmaßstab und Produktionsmaßstab, basierend auf Simulated Moving Bed (SMB = Gegenstrom Chromatographie) Technologie, sowie ein Modular Valve System (MSV) und dessen Verwendung in einem Verfahren zur Trennung eines Stoffgemisches.