PROCESS FOR PRODUCTION OF ALPHA-TRIFLUOROMETHYL- BETA-SUBSTITUTED- BETA -AMINO ACID

±-trifluoromethyl-²-substituted-²-amino acids can be produced by allowing ±-trifluoromethyl-²-substituted-±,²-unsaturated esters to react with hydroxylamine to convert ±-trifluoromethyl-²-substituted-±,²-unsaturated esters into dehydrogenated closed-ring body of ±-trifluoromethyl-²-substituted-²-ami...

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Bibliographische Detailangaben
Hauptverfasser: MOGI KAORI, YAMAZAKI TAKAKO, ISHII AKIHIRO, MASUDA TAKASHI, YASUMOTO MANABU
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:±-trifluoromethyl-²-substituted-²-amino acids can be produced by allowing ±-trifluoromethyl-²-substituted-±,²-unsaturated esters to react with hydroxylamine to convert ±-trifluoromethyl-²-substituted-±,²-unsaturated esters into dehydrogenated closed-ring body of ±-trifluoromethyl-²-substituted-²-amino acid, and by hydrogenolyzing the dehydrogenated closed-ring body. According to this production process, novel ±-trifluoromethyl-²-substituted-²-amino acids which are free amino acids whose functional groups are not protected can be produced, in which ²-position substituent is not limited to aromatic ring group or substituted aromatic ring group while the relative stereochemistry of ±-position and ²-position can be also controlled.