PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND

2-Aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) is produced with ease without decreasing the optical purity, by reacting optically active monochlorohydrin and aryl(halomethyl)ketone as starting materials in an acid catalyst. Furthermore, optically active (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)m...

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Bibliographische Detailangaben
Hauptverfasser: KAWASE, TAKAHIRO, ISHII, YUTAKA, MATSUI, YUMIKO, IWASHINA, SHINGO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:2-Aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) is produced with ease without decreasing the optical purity, by reacting optically active monochlorohydrin and aryl(halomethyl)ketone as starting materials in an acid catalyst. Furthermore, optically active (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl carboxylate and optically active (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl sulfonate, which are useful intermediates for ketoconazole, are efficiently produced from the obtained optically active form (A). In addition, optically active trans-(2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl carboxylate is isomerized to a cis form thereof in the presence of an acid catalyst.