Recombinant production of mixtures of antibodies

The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto, a nucleic acid sequence encoding a common light chain, and nucleic acid sequences encoding two different heavy chains are expressed in a recombinant host cell. The antibodies in mixtures accor...

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Bibliographische Detailangaben
Hauptverfasser:	Logtenberg, Ton, Bout, Abraham, Van Berkel, Patricius Hendrikus, Brus, Ronald Hendrik Peter
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto, a nucleic acid sequence encoding a common light chain, and nucleic acid sequences encoding two different heavy chains are expressed in a recombinant host cell. The antibodies in mixtures according to the invention comprise two different heavy chains capable of pairing to a common light chain, thereby forming functional antigen binding domains. Mixtures of antibodies, and use of these mixtures in a variety of field, are also provided by the invention.