TRICYCLIC NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIALS

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: wherein: one of Z1 and Z2 is CH or N and the other is CH; L is selected from: -CH2-CH CH-, -CH CH-CH2-, -(CH2)p- where p is 2, 3 or 4, -CH2-CH2-O-, -O-CH2-CH2-, -CH2-CH2-NH-, -HN-CH2-CH2-, -C(O)-CH CH-, -CH CH-C(O)-,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BARROS-AGUIRRE, DAVID, ALEMPARTE-GALLARDO, CARLOS, FIANDOR-ROMAN, JOSE, MARIA, REMUINAN-BLANCO, MODESTO, JESUS, CACHO-IZQUIERDO, MONICA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: wherein: one of Z1 and Z2 is CH or N and the other is CH; L is selected from: -CH2-CH CH-, -CH CH-CH2-, -(CH2)p- where p is 2, 3 or 4, -CH2-CH2-O-, -O-CH2-CH2-, -CH2-CH2-NH-, -HN-CH2-CH2-, -C(O)-CH CH-, -CH CH-C(O)-, -CH2-C≡C- or -C≡C-CH2-; U represents a cyclic group; m is 0 or 1, n is independently 0 or 1; and substituent(s) R5 and R6 are independently selected from: halo, CF3, OCF3, C1-3 alkyl, C1-3 alkoxy, nitro and cyano, pharmaceurtical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them.