N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed. Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed...

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Bibliographische Detailangaben
Hauptverfasser:	PAJOUHESH, Hassan, TAN, Jason, CHAKKA, Nagasree, KAUL, Ramesh, ZHU, Yongbao, ZHOU, Yuanxi, DING, Yanbing, GRIMWOOD, Mike, ZHANG, Lingyun
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed. Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators. Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as epilepsy are also disclosed.