3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases
This invention provides compounds of Formula (Ia): wherein: R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ; R 2 is heteroaryl, substituted wi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | HANSSON, TOMAS HEDEMYR, ANNABEL L. OLSEN ULLRICH, JOHN W CHENG, AIPING MILLER, CHRISTOPHER, P UNWALLA, RAYOMAND, J RHOENNSTAD, PATRIK, P STEFFAN, ROBERT J BOWEN, STEPHEN, M KRUGER, LARS MATELAN, EDWARD, M ZAMARATSKI, EDOUARD WROBEL, JAY, E |
| description | This invention provides compounds of Formula (Ia):
wherein:
R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ;
R 2 is heteroaryl, substituted with YD; or
R 2 is phenyl substituted with up to four substituents YD;
R 20 is H or C 1-3 alkyl; and
R 4 is H, halogen, methyl or methoxy;
and pharmaceutically acceptable salts thereof. The compounds and salts are useful in the treatment or inhibition of Liver X Receptor (LXR) mediated diseases. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2295429A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2295429A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2295429A13</originalsourceid><addsrcrecordid>eNqNyrEOgjAQgGEWB6O-w40wdAB0YDQG48BgDAMbOcuRNqktuSsk-vQy-ABO__D922QuVZoaisQhQ367TFk_4Cc4EkCBxi7E0AGTpikGhrTpHhmgH6A1KgfrjX3aFQTGVaMhiEwYX-QjhBE08mDDgqJnhwyDFUIh2SebEZ3Q4dddAte6vdwUTaEnmVCTp9jX96KoTseiOuflH8sXxXNCsw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases</title><source>esp@cenet</source><creator>HANSSON, TOMAS ; HEDEMYR, ANNABEL L. OLSEN ; ULLRICH, JOHN W ; CHENG, AIPING ; MILLER, CHRISTOPHER, P ; UNWALLA, RAYOMAND, J ; RHOENNSTAD, PATRIK, P ; STEFFAN, ROBERT J ; BOWEN, STEPHEN, M ; KRUGER, LARS ; MATELAN, EDWARD, M ; ZAMARATSKI, EDOUARD ; WROBEL, JAY, E</creator><creatorcontrib>HANSSON, TOMAS ; HEDEMYR, ANNABEL L. OLSEN ; ULLRICH, JOHN W ; CHENG, AIPING ; MILLER, CHRISTOPHER, P ; UNWALLA, RAYOMAND, J ; RHOENNSTAD, PATRIK, P ; STEFFAN, ROBERT J ; BOWEN, STEPHEN, M ; KRUGER, LARS ; MATELAN, EDWARD, M ; ZAMARATSKI, EDOUARD ; WROBEL, JAY, E</creatorcontrib><description>This invention provides compounds of Formula (Ia):
wherein:
R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ;
R 2 is heteroaryl, substituted with YD; or
R 2 is phenyl substituted with up to four substituents YD;
R 20 is H or C 1-3 alkyl; and
R 4 is H, halogen, methyl or methoxy;
and pharmaceutically acceptable salts thereof. The compounds and salts are useful in the treatment or inhibition of Liver X Receptor (LXR) mediated diseases.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110316&DB=EPODOC&CC=EP&NR=2295429A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110316&DB=EPODOC&CC=EP&NR=2295429A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANSSON, TOMAS</creatorcontrib><creatorcontrib>HEDEMYR, ANNABEL L. OLSEN</creatorcontrib><creatorcontrib>ULLRICH, JOHN W</creatorcontrib><creatorcontrib>CHENG, AIPING</creatorcontrib><creatorcontrib>MILLER, CHRISTOPHER, P</creatorcontrib><creatorcontrib>UNWALLA, RAYOMAND, J</creatorcontrib><creatorcontrib>RHOENNSTAD, PATRIK, P</creatorcontrib><creatorcontrib>STEFFAN, ROBERT J</creatorcontrib><creatorcontrib>BOWEN, STEPHEN, M</creatorcontrib><creatorcontrib>KRUGER, LARS</creatorcontrib><creatorcontrib>MATELAN, EDWARD, M</creatorcontrib><creatorcontrib>ZAMARATSKI, EDOUARD</creatorcontrib><creatorcontrib>WROBEL, JAY, E</creatorcontrib><title>3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases</title><description>This invention provides compounds of Formula (Ia):
wherein:
R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ;
R 2 is heteroaryl, substituted with YD; or
R 2 is phenyl substituted with up to four substituents YD;
R 20 is H or C 1-3 alkyl; and
R 4 is H, halogen, methyl or methoxy;
and pharmaceutically acceptable salts thereof. The compounds and salts are useful in the treatment or inhibition of Liver X Receptor (LXR) mediated diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEOgjAQgGEWB6O-w40wdAB0YDQG48BgDAMbOcuRNqktuSsk-vQy-ABO__D922QuVZoaisQhQ367TFk_4Cc4EkCBxi7E0AGTpikGhrTpHhmgH6A1KgfrjX3aFQTGVaMhiEwYX-QjhBE08mDDgqJnhwyDFUIh2SebEZ3Q4dddAte6vdwUTaEnmVCTp9jX96KoTseiOuflH8sXxXNCsw</recordid><startdate>20110316</startdate><enddate>20110316</enddate><creator>HANSSON, TOMAS</creator><creator>HEDEMYR, ANNABEL L. OLSEN</creator><creator>ULLRICH, JOHN W</creator><creator>CHENG, AIPING</creator><creator>MILLER, CHRISTOPHER, P</creator><creator>UNWALLA, RAYOMAND, J</creator><creator>RHOENNSTAD, PATRIK, P</creator><creator>STEFFAN, ROBERT J</creator><creator>BOWEN, STEPHEN, M</creator><creator>KRUGER, LARS</creator><creator>MATELAN, EDWARD, M</creator><creator>ZAMARATSKI, EDOUARD</creator><creator>WROBEL, JAY, E</creator><scope>EVB</scope></search><sort><creationdate>20110316</creationdate><title>3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases</title><author>HANSSON, TOMAS ; HEDEMYR, ANNABEL L. OLSEN ; ULLRICH, JOHN W ; CHENG, AIPING ; MILLER, CHRISTOPHER, P ; UNWALLA, RAYOMAND, J ; RHOENNSTAD, PATRIK, P ; STEFFAN, ROBERT J ; BOWEN, STEPHEN, M ; KRUGER, LARS ; MATELAN, EDWARD, M ; ZAMARATSKI, EDOUARD ; WROBEL, JAY, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2295429A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANSSON, TOMAS</creatorcontrib><creatorcontrib>HEDEMYR, ANNABEL L. OLSEN</creatorcontrib><creatorcontrib>ULLRICH, JOHN W</creatorcontrib><creatorcontrib>CHENG, AIPING</creatorcontrib><creatorcontrib>MILLER, CHRISTOPHER, P</creatorcontrib><creatorcontrib>UNWALLA, RAYOMAND, J</creatorcontrib><creatorcontrib>RHOENNSTAD, PATRIK, P</creatorcontrib><creatorcontrib>STEFFAN, ROBERT J</creatorcontrib><creatorcontrib>BOWEN, STEPHEN, M</creatorcontrib><creatorcontrib>KRUGER, LARS</creatorcontrib><creatorcontrib>MATELAN, EDWARD, M</creatorcontrib><creatorcontrib>ZAMARATSKI, EDOUARD</creatorcontrib><creatorcontrib>WROBEL, JAY, E</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANSSON, TOMAS</au><au>HEDEMYR, ANNABEL L. OLSEN</au><au>ULLRICH, JOHN W</au><au>CHENG, AIPING</au><au>MILLER, CHRISTOPHER, P</au><au>UNWALLA, RAYOMAND, J</au><au>RHOENNSTAD, PATRIK, P</au><au>STEFFAN, ROBERT J</au><au>BOWEN, STEPHEN, M</au><au>KRUGER, LARS</au><au>MATELAN, EDWARD, M</au><au>ZAMARATSKI, EDOUARD</au><au>WROBEL, JAY, E</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases</title><date>2011-03-16</date><risdate>2011</risdate><abstract>This invention provides compounds of Formula (Ia):
wherein:
R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ;
R 2 is heteroaryl, substituted with YD; or
R 2 is phenyl substituted with up to four substituents YD;
R 20 is H or C 1-3 alkyl; and
R 4 is H, halogen, methyl or methoxy;
and pharmaceutically acceptable salts thereof. The compounds and salts are useful in the treatment or inhibition of Liver X Receptor (LXR) mediated diseases.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP2295429A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T18%3A30%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HANSSON,%20TOMAS&rft.date=2011-03-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2295429A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |