3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases

3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases

This invention provides compounds of Formula (Ia): wherein: R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ; R 2 is heteroaryl, substituted wi...

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Hauptverfasser: HANSSON, TOMAS, HEDEMYR, ANNABEL L. OLSEN, ULLRICH, JOHN W, CHENG, AIPING, MILLER, CHRISTOPHER, P, UNWALLA, RAYOMAND, J, RHOENNSTAD, PATRIK, P, STEFFAN, ROBERT J, BOWEN, STEPHEN, M, KRUGER, LARS, MATELAN, EDWARD, M, ZAMARATSKI, EDOUARD, WROBEL, JAY, E
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention provides compounds of Formula (Ia): wherein: R 1 has various meanings including C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl, NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen and S(O) k R 5 ; R 2 is heteroaryl, substituted with YD; or R 2 is phenyl substituted with up to four substituents YD; R 20 is H or C 1-3 alkyl; and R 4 is H, halogen, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds and salts are useful in the treatment or inhibition of Liver X Receptor (LXR) mediated diseases.