MACROLIDES WITH VEGF TRANSCRIPTION SUPPRESSION ACTIVITY

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp....

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Bibliographische Detailangaben
Hauptverfasser:	YAMAMOTO, SATOSHI, TSUCHIDA, TOSHIO, SAKAI, TAKASHI, NAGAI, MITSUO, OKAMOTO, KIYOSHI, FUJITA, MASANORI, KOMEDA, KEISUKE, NIIJIMA, JUN, YAMADA, TOMONARI, OKUDA, AKIFUMI, YAMORI, TAKAO, YOSHIDA, MASASHI, KOTAKE, YOSHIHIKO, MATSUFUJI, MOTOKO, KISHI, KUMIKO, MIZUI, YOSHIHARU, NAKASHIMA, TAKASHI, KAWAMURA, NAOTO, DOBASHI, KAZUYUKI, UENAKA, TOSHIMITSU, ASAI, NAOKI, SAMESHIMA, TOMOHIRO, NORIHISA, KOJI, IWATA, MASAO, TAKEDA, SUSUMU
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.