Compositions and methods using MGD-CSF in disease treatment

The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID....

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Bibliographische Detailangaben
Hauptverfasser: BOSCH, ELIZABETH, DOBERSTEIN, STEVEN, LINNEMANN, THOMAS, BEHRENS, DIRK, LIN, HAISHAN, WILLIAMS, LEWIS, T, WU, GE, WONG, JUSTIN, G., P, MARSHALL, SHANNON, HESTIR, KEVIN, LEE, ERNESTINE, ZHOU, AILEEN, LEO, CINDY, HUANG, MIN, MEI, HALENBECK, ROBERT, FORGAN
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment