Pichia pastoris as a host for the production of the ribosome-inactivating protein (RIP) saporin and saporin fusion chimaeras

The present invention relates to the field of recombinant protein expression and discloses a procedure for the production of toxic chimaeric proteins endowed with ribosome-inactivating activity based on the plant toxin Saporin from Saponaria officinalis in the methylotrophic yeast Pichia pastoris .

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Bibliographische Detailangaben
Hauptverfasser:	FABBRINI, M. SERENA, FLAVELL, DAVID J, COLOMBATTI, MARCO, IPPOLITI, RODOLFO, LOMBARDI, ALESSIO, DELLA CRISTINA, PIETRO, CERIOTTI, ALDO, FLAVELL, SOPSAMORN U
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the field of recombinant protein expression and discloses a procedure for the production of toxic chimaeric proteins endowed with ribosome-inactivating activity based on the plant toxin Saporin from Saponaria officinalis in the methylotrophic yeast Pichia pastoris .