PHARMACEUTICAL FORMULATIONS COMPRISING A PEPTIDE COMPLEXED WITH A DIKETOPIPERAZINE

A method is provided for purifying a peptide or a protein comprising: providing a peptide or protein composition containing an impurity to be removed; forming a complex of the active agent with a complexing agent thereby displacing the impurity; and, removing essentially all of the impurity from the...

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Bibliographische Detailangaben
Hauptverfasser:	STEINER, SOLOMON S, SULNER, JOSEPH W, WOODS, RODNEY J
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY NANOTECHNOLOGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING
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Beschreibung
Zusammenfassung:	A method is provided for purifying a peptide or a protein comprising: providing a peptide or protein composition containing an impurity to be removed; forming a complex of the active agent with a complexing agent thereby displacing the impurity; and, removing essentially all of the impurity from the complex. A composition is provided comprising such a purified peptide complexed with a complexing agent. Microparticles comprising monomeric or dimeric insulin complexed with a complexing agent, wherein the insulin is substantially free of zinc, may be used in medicine to deliver insulin to a patient. Also provided is a formulation for use in medicine comprising insulin complexed with a complexing agent which, when administered to a patient in an effective amount, produces a peak blood insulin concentration in the patient that simulates a normal response to eating, wherein the formulation is suitable for non-intravenous administration.