MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS

MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS

The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the tre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FENG, HAO, YUE, EDDY, W, ZHU, WENYU, COMBS, ANDREW, PAUL, BOWER, MICHAEL, JASON, SPARKS, RICHARD, B
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.