Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme

The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes,...

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Hauptverfasser: PATEL, JYOTI, R, DINGES, JURGEN, SHUAI, QI, WINN, MARTIN, ROHDE, JEFFREY, J, YONG, HONG, LINK, JAMES, T, YEH, VINCE, S, SORENSEN, BRYAN, K
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.