2,4-di[(hetero)arylamino]-pyrimidine derivatives as zap-70 and/or syk inhibitors

2,4-di[(hetero)arylamino]-pyrimidine derivatives as zap-70 and/or syk inhibitors

Disclosed are pyrimidine derivatives of formula wherein R 0 , R 1 , R 3 to R 9 , and Z have a signification as indicated in claim 1, which have ZAP-70 and/or Syk inhibitory activities.

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Bibliographische Detailangaben
Hauptverfasser: DUTHALER, RUDOLF, BAENTELI, ROLF, HINTERDING, KLAUS, THOMA, GEBHARD, WALLISER, LOUIS, BUEHLMAYER, PETER, VAN EIS, MAURICE, ZENKE, GERHARD, VON MATT, ANETTE, BERNHARD, MARIE, COOKE, NIGEL
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are pyrimidine derivatives of formula wherein R 0 , R 1 , R 3 to R 9 , and Z have a signification as indicated in claim 1, which have ZAP-70 and/or Syk inhibitory activities.