Method for specifically located synthesis of biopolymers on solid carriers

Type-specific synthesis of bio-polymers of a defined sequence on pre-determined ranges of a solid carrier comprises gradual coupling of monomer and/or oligomer components (I); where, before the coupling step, at least a pre-determined area of the carrier are activated for coupling of (I) to activate the reactive groups; and the temporary group for protection are removed by addition of an activation reagent in aqueous solution, is new. Independent claims are also included for: (1) a procedure for the type-specific synthesis of biopolymers of a defined sequence on pre-determined ranges of solid carrier, comprising: (a) arranging a mask on the carrier (for coupling of (I) of the biopolymer, which is to be synthesized for controlling available reactive groups with protection groups to the carrier); (b) activating the reactive groups by removing the temporary protective groups at the ranges given by the mask, by adding the activation reagent in aqueous solution; (c) coupling (I) with activated reactive groups; and (d) repeating step (a) to (c), until the desired biopolymers is synthesized; (2) a micro array prepared by the process; and (3) a micro array with pre-determined ranges immobilized biopolymer probes, where the proportional portion P at biopolymers, which exhibits the desired number of monomer M, is given by the formula P = S-M (where S is an average step yield with the coupling of (I); and the density at pre-determined ranges is at least 1500 spots per cm 2>and the average step yield is 95 (preferably 98) %).