Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages

The present invention provides a biosafe and useful vector to transfer genetic material to CD14+ mononuclear cells (monocytcs and monocytc-dcrivcd macrophagcs) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short...

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Bibliographische Detailangaben
Hauptverfasser:	RIO FERNANDEZ, ADOLFO, FERNANDEZ GIMENO, ESTER, GASSULL DURO, MIQUEL ANGEL, CHILLON RODRIGUEZ, MIGUEL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a biosafe and useful vector to transfer genetic material to CD14+ mononuclear cells (monocytcs and monocytc-dcrivcd macrophagcs) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells.