PROCESS FOR THE PREPARATION OF (S)-1-ALKYL-2',6'-PIPECOLOXYLIDIDE COMPOUND

PROCESS FOR THE PREPARATION OF (S)-1-ALKYL-2',6'-PIPECOLOXYLIDIDE COMPOUND

The present invention relates to an improved process for the preparation of high chiral purity (S)-1-alkyl-2',6'-Pipecoloxylidide compound such as Ropivacaine, Levobupivacaine or salts thereof, which comprises crystallization of (S)-1-alkyl-2',6'- Pipecoloxylidide acid addition s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KOFTIS, THEOCHARIS, LITHADIOTI, ALEXANDRA, SONI, ROHIT, RAVIKANT, GEORGOPOULOU, IONNA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to an improved process for the preparation of high chiral purity (S)-1-alkyl-2',6'-Pipecoloxylidide compound such as Ropivacaine, Levobupivacaine or salts thereof, which comprises crystallization of (S)-1-alkyl-2',6'- Pipecoloxylidide acid addition salt in a non-alcoholic and non-ketonic solvent.