DIAMIDO THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

DIAMIDO THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel Diamido Thiazole Derivatives of structure I, compositions comprising the Diamido Thiazole Derivatives, and methods for using the Diamido Thiazole Derivatives for treating or preventing a proliferative disorder, an anti -proliferative disorder, inflammation, art...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SIDDIQUI, M. ARSHAD, WONG, TZU, T, LABROLI, MARC, A, POKER, CORY, SETH, REDDY, PANDURANGA, ADULLA, P, GUZI, TIMOTHY, J
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel Diamido Thiazole Derivatives of structure I, compositions comprising the Diamido Thiazole Derivatives, and methods for using the Diamido Thiazole Derivatives for treating or preventing a proliferative disorder, an anti -proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. Formula (I) wherein: M is -C(O)-, -C(S)-. -S(O)-. -S(O)2-. -NHS(O)2-. -OC(O)- or -NHC(O)-; Q is:formula (II).