ELECTROPHYSIOLOGY METHODS FOR IDENTIFICATION OF PROTEIN STRUCTURES IN MEMBRANES ASSOCIATED TO NEURODEGENERATIVE DISEASES

ELECTROPHYSIOLOGY METHODS FOR IDENTIFICATION OF PROTEIN STRUCTURES IN MEMBRANES ASSOCIATED TO NEURODEGENERATIVE DISEASES

This invention corresponds to an in vitro method that employs an electrophysiology technique; in particular, an embodiment of the patch-clamp technique in its perforated type, which will allow us evaluating the neurotoxic capacity of protein structures associated to the generation of neurodegenerati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OPAZO MARTINEZ, CARLOS ROBERTO, PARODI RIVERA, JORGE LUIS, AGUAYO HERNANDEZ, LUIS GERARDO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:This invention corresponds to an in vitro method that employs an electrophysiology technique; in particular, an embodiment of the patch-clamp technique in its perforated type, which will allow us evaluating the neurotoxic capacity of protein structures associated to the generation of neurodegenerative diseases. It addition, it allows evaluating potential pharmacologic capacities of candidate molecules (drugs) in order to prevent, treat, or cure the said diseases. The invention involves the use of peptides that cause neurodegenerative diseases in order to form a spontaneous perforated recording that only occurs with peptides in the patch clamp glass pipette.