IN VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS

The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics,...

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Bibliographische Detailangaben
Hauptverfasser:	PIERCE, J. MICHAEL, DALTON, STEPHEN, ATWOOD, JAMES, A, YORK, WILLIAM, S, WELLS, ROBERT, LANCE, ORLANDO, RONALD, C, MOREMEN, KELLEY, W, TIEMEYER, MICHAEL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.