MULTI-BLOCK COPOLYMERS

MULTI-BLOCK COPOLYMERS

A multi-block copolymer comprises at least one hydrophilic collagen-like block and at least one silk-like block. The silk-like block comprises an amino acid sequence ((GA) m GX) n , wherein G is glycine, A is alanine, m and n are at least 2. X is an ionizable amino acid. The ionizable amino acid is...

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Bibliographische Detailangaben
Hauptverfasser: COHEN STUART, MARTIEN, MARTENS, AERNOUT ANDERS, EGGINK, GERRIT, DE WOLF, FREDERIK ANTON, WERTEN, MARC WILLEM THEODOOR
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:A multi-block copolymer comprises at least one hydrophilic collagen-like block and at least one silk-like block. The silk-like block comprises an amino acid sequence ((GA) m GX) n , wherein G is glycine, A is alanine, m and n are at least 2. X is an ionizable amino acid. The ionizable amino acid is inducible to bear a positive charge or a negative charge. The ionizable amino acid bearing the positive charge is preferably histidine and the one bearing the negative charge is preferably glutamic acid.