NOVEL METHODS AND ANTIBODIES FOR TREATING CANCER

The invention relates to novel methods for the treatment of tumors, comprising administration of a bispecific antibody or a combination of two or more non-cross-blocking antibodies that recognize the same target antigen or antigenic complex. In particular, the invention relates to a method for induc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	VAN DE WINKEL, JAN, PARREN, PAUL, VALERIUS, THOMAS, LAMMERTS VAN BUEREN, JEROEN, BERGER, SVEN, WEISNER, WENCKE, BLEEKER, WILLEM, KAREL, DECHANT, MICHAEL, EDVARDSEN, KLAUS
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to novel methods for the treatment of tumors, comprising administration of a bispecific antibody or a combination of two or more non-cross-blocking antibodies that recognize the same target antigen or antigenic complex. In particular, the invention relates to a method for inducing complement-mediated cell killing in the treatment of a tumor, said method comprising combined administration, to a human being in need thereof, of a first antibody and a second antibody, wherein said first antibody binds EGFR, said second antibody binds EGFR, said first and second antibody are non-cross-blocking, and the dosage regimen is such that CDC is obtained at the tumor site.