Knock-out animal models for novel genes and methods of use

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in a PRO618 gene. Such in vivo studies and characterizations may provide val...

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Bibliographische Detailangaben
Hauptverfasser:	SPARKS, MARY JEAN, RANGEL, CAROLINA, COMBS, KATHERIN, CULBERTSON, LING LING, STALA, JOY, SHI, ZHENG-ZHENG, MCLAIN, DINA REBECCA, VOGEL, PETER, MONTGOMERY, CHUCK, PHILLIPS, HEIDI, PAYNE, BOBBY JOE, DING, ZHIYONG, JUNGE, HAROLD, QIAN, NI NANCY, EDWARDS, JOEL, DESAUVAGE, FREDERIC, GIRGIS, ROSEMARY, JUNUTULA, JAGATH REDDY, BYERS-HORNER, ALLISON ANNE, MASSEY, ERIN MARIE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in a PRO618 gene. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.