PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED AMINES

A process for preparing enantiomerically enriched amines by reacting a ketone with ammonia or an ammonium salt and a reducing agent in the presence of a catalytic system comprising the components: a) an amino acid transaminase, b) an alpha-amino acid which is a substrate of the amino acid transamina...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	GROEGER, HARALD, DODERER, KAI, ROLLMANN, CLAUDIA, WIENAND, WOLFGANG
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A process for preparing enantiomerically enriched amines by reacting a ketone with ammonia or an ammonium salt and a reducing agent in the presence of a catalytic system comprising the components: a) an amino acid transaminase, b) an alpha-amino acid which is a substrate of the amino acid transaminase, c) an amino acid dehydrogenase suitable for preparing the alpha-amino acid, d) NAD(P)+ and e) an NAD(P)+-reducing enzyme, which reacts NAD(P)+ with the reducing agent to give NAD(P)H. The process can be carried out with catalytic amounts of alpha-amino acid and NAD(P)+, and enables an enantioselective reductive amination of ketones.