METHOD FOR INDUCTION OF DIFFERENTIATION OF ES CELL

It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing a mammal-...

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Bibliographische Detailangaben
Hauptverfasser: KUME, SHOEN, KUME, KAZUHIKO, SHIRAKI, NOBUAKI, UMEDA, KAHOKO
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing a mammal-derived ES cell in the presence of activin and bFGF, and then culturing the ES cell in the presence of dexamethasone, HGF, and oncostatin M.