PHARMACEUTICAL FORMULATION COMPRISING AN INSULIN DERIVATIVE

PHARMACEUTICAL FORMULATION COMPRISING AN INSULIN DERIVATIVE

The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HAVELUND, Svend, HUUS, Kasper, POULSEN, Christian, STEENSGAARD, Dorte Bjerre, HUBALEK, Frantisek
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase the tendency of the insulin derivative to self-associate into dodecamers. The invention further comprises a process for preparing the soluble pharmaceutical formulation.