HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF

The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, WEON SUP, LEE, JOON CHUL, JEON, JAE WON, SUL, SAM SOOK, JANG, HYUN SOOK, PYUN, BO JEONG, KIM, SUNG WOO, YOO, JIN SAN, LEE, DONG SUP, SHIM, SANG RYEOL, KANG, JEONG EUN, KIM, NAHM JU, PARK, MI HEE, LEE, DONG HEON, KIM, SEMI, KOH, SANG SEOK, KIM, KWI HWA, CHO, TOO HYON, RHA, GEUN BAE, YOO, HYEON MI, KIM, DO YUN, KWON, YOUNG GUEN, YUN, CHAE OK, PARK, YOUNG WOO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment.