Indolyamides as modulators for an EP2 receptor

Substituted indole compounds (I) and their isomers, diastereomers, enantiomers, salts or cyclodextrin clathrate, are new. Substituted indole compounds of formula (I) and their isomers, diastereomers, enantiomers, salts or cyclodextrin clathrate, are new. X : CH or N; Y 1>O, N, S, NH,-CH=N-, -N=CH-, -N=N- or -CH=CH- (when X is N); R 1>H or 1-6C alkyl (optionally substituted); R 2>1-4C alkoxy or 1-6C alkyl (both can be arbitrarily substituted), H, halo, CN or -S(O) q-CH 3; q : 0-2; R 3>H, 1-4C alkoxy or halo; R 4>H or F; R 5>H or halo; R 6>, R 9>H, F or Cl; R 7>H or R 10>, provided that when R 7>is H, then R 8>is R 10>, and when R 8>is H, then R 7>is R 10>; R 10>-CONH-R 11>or CO-NR 11>R 12>; R 11>, R 12>1-6C alkyl (which is substituted with one or more -S(O) p-R 13>, OH, CN, COOH, CO-NH 2, SO 2NH 2, SO 2NH-R 13>, CO-NH-SO 2-R 13>, SO 2-NH-CO-R 13>, 1-6C acyl, OR 13>, CO 2-R 13>,-NR 13>R 14>, NH-R 13>, CO-NHR 13>, CO-NR 13>R 14>, NH-COR 13>, NH-SO 2R 13>, NR 15>-COR 13>, NH-CONH 2, NH-CO-NHR 13>, NH-CO-NR 13>R 14>, NR 15>-CO-NH-R 13>or NR 15>-CO-N(1-6C alkyl)-R 13>, or 6-12C aryl, 5-12C heteroaryl or 3-6C cycloalkyl (all substituted with 1 or 2 substituents of T)), or 3-6C cycloalkyl, 6-12C aryl or 5-12C heteroaryl (all substituted with 1-3 substituents of T, NH-(3-6C cycloalkyl), CO-NH(1-6C-alkyl) or CON(1-6C-alkyl) 2); T : CONH 2, SO 2NH 2, CONHCH 3, CON(CH 3) 2, SO 2NHCH 3, CO-NH-SO 2CH 3or 1-6C acyl; either R 13>-R 15>1-6C-alkyl, 3-6C-cycloalkyl, 6-12C-aryl, 5-12C-heteroaryl, CH 2-6-12C-aryl or CH 2-5-12C-heteroaryl; or R 13>R 15>together with N-CO-N-CO-NH group : 5 or 6 membered ring, which optionally contains additional heteroatoms and substituted one, two or three times, by halo, amino, OH, CN or 1-6C-alkyl that optionally substituted; and p : 0-2. Independent claims are included for: (1) the preparation of (I); and (2) a medicament comprising (I) in combination with a cyclooxygenase inhibitor, which are aspirin, naproxen, indomethacin, meloxicam, ibuprofen, celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide), parecoxib (N-[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonylpropionamide), rofecoxib (4-(4-mesylphenyl)-3-phenylfuran-2(5H)-one), valdecoxib (4-[5-methyl-3-phenyl-4-isoxazoyl)] benzenesulfonamide, NS-398 (N-methyl-2-cyclohexanoxy-4-nitrobenzenesulfonamide), lumiracoxib [2-(2'-chloro-6'-fluorophenyl)]-amino-5-methylbenzeneacetic acid, ceracoxib and etoricoxib. [Image] ACTIVITY : Antiinfertility; Gynecologic