PIM KINASE INHIBITORS AND METHODS OF THEIR USE

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine...

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Bibliographische Detailangaben
Hauptverfasser: SHAFER, CYNTHIA, NISHIGUCHI, GISELE, WALTER, ANNETTE, BURGER, MATTHEW, GARCIA, PABLO, HAN, WOOSEOK, HUH, KAY, BELLAMACINA, CORNELIA, ANTONIOS-MCCREA, WILLIAM, JR, MCBRIDE, CHRISTOPHER, LAN, JIONG, LINDVALL, MIKA, ATALLAH, GORDANA, ZAVOROTINSKAYA, TATIANA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.