NEURONAL EXOCYTOSIS INHIBITING PEPTIDES
The invention relates to peptides of general formula (I): R 1 -AA-R 2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of...
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| creator | VAN DEN NEST, WIM CEBRIAN PUCHE, JOAN FERRER MONTIEL, ANTONIO PONSATI OBIOLS, BERTA CARREÑO SERRAIMA, CHRISTINA FERNANDEZ CARNEADO, JIMENA ALMIÑANA DOMENECH, NURIA |
| description | The invention relates to peptides of general formula (I):
R 1 -AA-R 2 (I)
which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin. |
| format | Patent |
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R 1 -AA-R 2 (I)
which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091125&DB=EPODOC&CC=EP&NR=2123673A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091125&DB=EPODOC&CC=EP&NR=2123673A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN DEN NEST, WIM</creatorcontrib><creatorcontrib>CEBRIAN PUCHE, JOAN</creatorcontrib><creatorcontrib>FERRER MONTIEL, ANTONIO</creatorcontrib><creatorcontrib>PONSATI OBIOLS, BERTA</creatorcontrib><creatorcontrib>CARREÑO SERRAIMA, CHRISTINA</creatorcontrib><creatorcontrib>FERNANDEZ CARNEADO, JIMENA</creatorcontrib><creatorcontrib>ALMIÑANA DOMENECH, NURIA</creatorcontrib><title>NEURONAL EXOCYTOSIS INHIBITING PEPTIDES</title><description>The invention relates to peptides of general formula (I):
R 1 -AA-R 2 (I)
which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD3cw0N8vdz9FFwjfB3jgzxD_YMVvD08_B08gzx9HNXCHANCPF0cQ3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgFGhkbGZubGjobGRCgBAMpRI8c</recordid><startdate>20091125</startdate><enddate>20091125</enddate><creator>VAN DEN NEST, WIM</creator><creator>CEBRIAN PUCHE, JOAN</creator><creator>FERRER MONTIEL, ANTONIO</creator><creator>PONSATI OBIOLS, BERTA</creator><creator>CARREÑO SERRAIMA, CHRISTINA</creator><creator>FERNANDEZ CARNEADO, JIMENA</creator><creator>ALMIÑANA DOMENECH, NURIA</creator><scope>EVB</scope></search><sort><creationdate>20091125</creationdate><title>NEURONAL EXOCYTOSIS INHIBITING PEPTIDES</title><author>VAN DEN NEST, WIM ; CEBRIAN PUCHE, JOAN ; FERRER MONTIEL, ANTONIO ; PONSATI OBIOLS, BERTA ; CARREÑO SERRAIMA, CHRISTINA ; FERNANDEZ CARNEADO, JIMENA ; ALMIÑANA DOMENECH, NURIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2123673A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN DEN NEST, WIM</creatorcontrib><creatorcontrib>CEBRIAN PUCHE, JOAN</creatorcontrib><creatorcontrib>FERRER MONTIEL, ANTONIO</creatorcontrib><creatorcontrib>PONSATI OBIOLS, BERTA</creatorcontrib><creatorcontrib>CARREÑO SERRAIMA, CHRISTINA</creatorcontrib><creatorcontrib>FERNANDEZ CARNEADO, JIMENA</creatorcontrib><creatorcontrib>ALMIÑANA DOMENECH, NURIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN DEN NEST, WIM</au><au>CEBRIAN PUCHE, JOAN</au><au>FERRER MONTIEL, ANTONIO</au><au>PONSATI OBIOLS, BERTA</au><au>CARREÑO SERRAIMA, CHRISTINA</au><au>FERNANDEZ CARNEADO, JIMENA</au><au>ALMIÑANA DOMENECH, NURIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEURONAL EXOCYTOSIS INHIBITING PEPTIDES</title><date>2009-11-25</date><risdate>2009</risdate><abstract>The invention relates to peptides of general formula (I):
R 1 -AA-R 2 (I)
which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS |
| title | NEURONAL EXOCYTOSIS INHIBITING PEPTIDES |
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