NEURONAL EXOCYTOSIS INHIBITING PEPTIDES

The invention relates to peptides of general formula (I): R 1 -AA-R 2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DEN NEST, WIM, CEBRIAN PUCHE, JOAN, FERRER MONTIEL, ANTONIO, PONSATI OBIOLS, BERTA, CARREÑO SERRAIMA, CHRISTINA, FERNANDEZ CARNEADO, JIMENA, ALMIÑANA DOMENECH, NURIA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to peptides of general formula (I): R 1 -AA-R 2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R 2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R 1 is H or acetyl, R 2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.