NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on A² aggregation, a degradative effect on A² aggregates, an inhibitory effect on ²-secretase, and a protective effect on neurons. The novel compound is a compound represented by the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SHIMMYO, YOSHIARI, KIHARA, TAKESHI, SUGIMOTO, HACHIRO, HIJIKURO, ICHIRO, NIIDOME, TETSUHIRO, TAKAHASHI, TAKASHI
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on A² aggregation, a degradative effect on A² aggregates, an inhibitory effect on ²-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R 1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R 2 represents a 1H-indol-6-yl group or the like.