USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE

USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE

The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treati...

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Bibliographische Detailangaben
Hauptverfasser: LEE, S., PAUL, BUBER, M.N., TULU, CERNE, ROK, BRYANT, ROBERT, MORGAN, GILLIAN, SALEMME, F., RAYMOND, ZHOU, PEIHONG
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.