DEVELOPABLE BIODEGRADABLE MICROSPHERIC BLOOD VESSEL EMBOLISM MATERIALS

A radiopaque biodegradable vascular embolic microsphere comprises of a biodegradable material and a radiopaque material which can be both delivered to the vascular system, in which, the biodegradable material incorporates the radiopaque material to form granule structure. The embolic microsphere, readily visible under X-ray, can be delivered or drift with blood flow to a peripheral vessel or site, and can be manufactured using a simple process. A radiopaque biodegradable vascular embolic microsphere incorporating therapeutic agent(s) comprises of a biodegradable material, a radiopaque material, and therapeutic agent(s), which can be all delivered to the vascular system, in which, the biodegradable material incorporates the radiopaque material and the therapeutic agent to form granule structure. This embolic microsphere can be delivered to the targeted site under X-ray guidance, and then embolize the site, and release the therapeutic agent directly at the targeted site while degrading in vivo .