Heterocyclyl pyrimidines

Heterocyclyl-pyrimidine compounds (I) and their salts are new. Heterocyclyl-pyrimidine compounds of formula (I) and their salts are new. X : alkyl or phenyl (both optionally substituted), H, halo or CN; Z : alkoxy, alkylthio or alkylsulfonyl (all optionally substituted) or -N(R 1>)-R 2>; Y 1>aryl, heterocyclyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, arylalkyl, amino, 1-8C alkoxy, 1-8C alkylthio, 6-10C aryloxy, 6-10C arylthio, heterocyclyloxy, 6-10C aryl-1-4C alkoxy, 6-10C aryl-1-4C alkylthio, heterocyclyl-(1-4C)-alkoxy or heterocyclyl-(1-4C)-alkylthio (all optionally substituted) or halo; A : 3-10 membered saturated, partially unsaturated or aromatic mono- or bicyclic heterocycle containing up to 4 heteroatom comprising O, N or S (optionally substituted by 1-3 R1d); R1d : halo, OH, CN, oxo, nitro, amino, mercapto, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl, 2-6C alkynyl, 3-6C cycloalkyl, 1-6C alkoxy, 1-6C haloalkoxy, 1-7C alkylcarbonylamino, 1-6C alkylamino, di-(1-6C alkyl)amino, 1-6C alkylthio, 1-6C alkylsulfinyl, 1-6C alkylsulfonyl, aminosulfonyl, 1-6C alkylaminosulfonyl or di-(1-6C alkyl)aminosulfonyl; W 1>-N(R 4>)-R 5>or (-N ->-R 5>)(M 1>); either R 1>H, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, heterocyclyl, OH, alkoxy, amine, alkylamine, dialkylamine, hydroxyalkyl, alkylcarbonyloxyalkyl or alkyloxycarbonyloxyalkyl; and R 2>H or alkyl; or NR 1>R 2>heterocyclic ring (optionally substituted); R 4>alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heteroaryl, arylalkyl, heteroarylalkyl or optionally saturated heterocyclyl (all optionally substituted) or H; M 1>cation; R 5>saturated, partially or completely unsaturated or aromatic, optionally substituted 5- or 6-ring heterocyclyl (containing one or up to three further heteroatom comprising N, S and\or O atom, where O atom may not be adjacent), COR 7>, S(O) 1 - 2R 7>, CN, COOR 7>, CON(R 7>)-R 8>, P(=L)(R 9>)-R 1> 0>or CON=S(R 1> 1>)-(R 1> 2>); L : O or S; either R 7>H, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl-alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; and R 8>alkyl, alkenyl, alkynyl or alkoxy (optionally substituted), H or NH-R 4>; or NR 7>R 8>optionally substituted and saturated ring (optionally interrupted by further heteroatom); either R 9>, R 1> 0>optionally substituted alkyl, alkenyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkylalkoxy, alkylthio, alkenylthio, phenoxy, phenylthio, benzyloxy, benzylthio, heteroaryloxy, het