CRYSTALLINE COMPOSITION OF GM-CSF/GM-CSFR

The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony stimulating factor (GM-CSF) and its receptor (GM-CSFR). The present invention further provides methods for t...

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Bibliographische Detailangaben
Hauptverfasser: PARKER, MICHAEL, WILLIAM, HERCUS, TIMOTHY, ROBERT, LOPEZ, ANGEL, FRANCISCO, MCKINSTRY, WILLIAM, JOHN, HANSEN, GUIDO
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony stimulating factor (GM-CSF) and its receptor (GM-CSFR). The present invention further provides methods for the design and selection of modulators of GM-CSF/GM-CSFR interaction and signaling as well as signaling of other cytokines.