POLYMERIC DERIVATIVE OF NUCLEIC ACID METABOLIC ANTAGONIST

[PROBLEMS] A derivative of a nucleic acid antimetabolite is demanded which can show a higher therapeutic effect at a lower dose. [MEANS FOR SOLVING PROBLEMS] Disclosed is a high molecular weight derivative a nucleic acid antimetabolite, which is characterized by comprising a high molecular weight co...

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Bibliographische Detailangaben
Hauptverfasser:	TAKASHIO, KAZUTOSHI, YAMAMOTO, KEIICHIRO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	[PROBLEMS] A derivative of a nucleic acid antimetabolite is demanded which can show a higher therapeutic effect at a lower dose. [MEANS FOR SOLVING PROBLEMS] Disclosed is a high molecular weight derivative a nucleic acid antimetabolite, which is characterized by comprising a high molecular weight compound comprising a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a nucleoside derivative which can act as a nucleic acid antimetabolite, wherein the nucleoside derivative is bound to the carboxyl group in the side chain of the high molecular weight compound via a highly hydrophobic linker.